Ketamine has been shown to relieve depression-like symptoms in animal studies. With human volunteers, researchers Sounak Mohanta and Yuri Saalmann concluded that the drug blocks “negative predictions” that are prominent in depressed patients.
UW News
Microbes help hibernating animals recycle nutrients, maintain muscle through winter
The discovery could help people with muscle-wasting disorders and even astronauts on extended space voyages by putting space travelers into a hibernation-like state.
Current anti-COVID pills work well against omicron, but antibody drugs are less effective
Public health officials expect antiviral pills to become an increasingly common treatment for COVID-19 that will reduce the severity of the disease in at-risk patients and decrease the burden of the pandemic.
UW–Madison researchers lead effort to create a universal coronavirus vaccine
If the world already had a pan-coronavirus vaccine in March 2020, it could have served as a mitigation tool until vaccines specific to SARS-CoV-2 could be developed.
Boosting one gene in the brain’s helper cells slows Alzheimer’s progression in mice
High activity of the gene, Nrf2, slowed cognitive and physical decline in the mice and reduced the accumulation of sticky proteins in their brains, all key markers of the disease in humans.
Seizures and memory problems in epilepsy may have a common cause
A new study could lead to earlier diagnosis of epilepsy and possibly new ways to treat epilepsy and other disorders that share symptoms, like Alzheimer’s disease, traumatic brain injury and autism spectrum disorder.
Promising treatment for Alexander disease moves from rat model to human clinical trials
The rare neurological disorder has no cure and is typically fatal, but a study led by UW–Madison researchers is a significant step in efforts to help people with the disease.
New technique, effective in mice, could help advance the use of probiotics
Researchers in the School of Pharmacy, led by Quanyin Hu, have developed a system that can keep probiotic bacteria alive in the lower intestine long enough to help treat or prevent colitis in a mouse model of the disease.
Combining low-dose radiotherapy with immunotherapy eradicates metastatic cancer in mice
UW–Madison and University of Pittsburgh scientists report the method works even when the radiation is given in doses too low to destroy the cancer outright.
Self-powered implantable device stimulates fast bone healing, then disappears without a trace
The thin, flexible device is bioresorbable, so once the bone is knitted back together, the device’s components dissolve within the body.