Some microbes in the guts of humans and mice may help control the buildup of plaque in arteries, the leading cause of cardiovascular disease, by gobbling up a group of inflammatory chemicals before they can circulate in the body.
animal research
Brain-penetrating drug candidate effective against deadly encephalitis viruses
The multidisciplinary team of researchers found that BDGR-49 protects mice infected with deadly eastern equine encephalitis virus (EEEV) or Venezuelan equine encephalitis virus (VEEV).
New drug delivery method harnesses clotting to target anti-cancer drugs at tumors
Researchers found that in mice that received the engineered proteins via intravenous injections, the proteins led to clot formation almost exclusively within tumors, with only very limited thrombosis occurring elsewhere.
UW researchers identify cell type that could be key to preventing marrow transplant complication
UW researchers at the Carbone Cancer Center have identified the cells that can cause graft-versus-host disease, the most common complication of bone marrow transplants.
New funding to protect bats from fungal epidemic hinges on UW–Madison discoveries
Researchers will investigate a multi-pronged approach to protecting wild bats against Pseudogymnoascus destructans, the fungus that causes white-nose syndrome.
New nanocapsules deliver therapy brain-wide, edit Alzheimer’s gene in mice
UW researchers have found a way to move gene therapies through the blood-brain barrier, a crucial step for brain-wide CRISPR treatments of disorders like Alzheimer’s and Parkinson’s disease.
Probiotic ‘backpacks’ show promise for treating inflammatory bowel diseases
UW researchers demonstrate just how much promise some well-equipped bacteria hold for improved inflammatory bowel disease treatments.
Brain-gut connection may reveal way to prevent cocaine addiction
Cocaine disrupts the balance of microbes in the guts of mice, part of a cycle of waxing and waning neurochemicals that can enhance the drug’s effects in the brain. But the same chemicals may also be harnessed to prevent addiction, according to new research.
Study shows differences between brains of primates — humans, other apes and monkeys — are small but significant
The cellular differences between these species may illuminate steps in their evolution and how those differences can be implicated in disorders, such as autism and intellectual disabilities, seen in humans.
Wild primate virus has pandemic potential should it jump the species barrier, shows study
New research demonstrates the potential for a family of viruses in African primates to jump the species barrier to humans.